A Guide to AMPK Activators
AMPK is the regulator that is maintaining cellular energy homeostasis which is basically the foundation of the body’s functionality. Now in mammals, AMPK is regulating the energy balance at both on cellular level by means of sensing ATP/AMP and ATP/ADP ratio levels and whole body level through response to the hormones and the brain.
ATP is actually the most significant energy molecule present in the body. In essence, this is the starting point of cellular function. ATP breaks down into ADP that has less potential for energy since the cells are using energy. Then after, ADP breaks down to AMP that has got the least energy potential among all 3. As a matter of fact, this is where AMPK becomes crucial by sensing if there is appropriate ratio among ATP/ADP/AMP and from there, tells the body if it requires more ADP to function properly.
AMPK acts on various processes through different mechanisms. This totally makes sense because it’s the master regulator of the functioning of cells. AMPK activation has an impact on the body which depends on the balance of signaling pathways and factors. Even so, there are some accepted benefits of increased AMPK activation including:
Anti aging – as we age, comes along with the gradual decline of AMPK activation. Experts actually think that AMPK is one of the contributing factors of aging. AMPK is important because it helps in having adequate level of new mitochondria and promotes cellular renewal as well.
Anti inflammation – inflammation decreases the level of AMPK activation in the body but what’s interesting is that, AMPK is used as well to decrease inflammation.
Anti diabetic – as a matter of fact, AMPK is slowly becoming well understood in relation to its role in diabetes treatment primarily because of its capability to enhance insulin sensitivity.
Basically, there are more and more nutritional products and herbal products/constituents discovered that are very effective in AMPK activator to which some include:
Number 1. AICAR – this is the analog of AMP which is needed in cellular use and storage similar to ATP. Since it’s the analog of AMP, AICAR can stimulate AMPK’s activity directly which can then improve muscle performance.
Number 2. ALA – in this case, it’s Alpha Lipoic Acid that is known to be an effective antioxidant but it’s a useful AMPK activator too. It’s been shown to boost the sensitivity of insulin in the body and also, carries anti obesity effects.
Number 3. Green tea extract – actually, this was discovered to assist in the activation of AMPK by activating upstream kinase.
Number 4. Berberine – with AMPK activation, berberine was known to bring the same anti diabetic effect as metformin.